Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Abstract Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen a significant effect on COPD pathology is unclear. This study aimed to identify specific IgE related clinical features diagnosis asthma-COPD overlap (ACO). Methods We recruited 76 patients with analyzed 39 using panel test (View Allergy ® ). ACO was diagnosed according Japanese Respiratory Society Guidelines. Results As for perennial aeroallergens, positivity moth (31.5%), Candida (23.7%), Dermatophagoides pteronyssinus (22.4%) house dust (22.4%), concerning pollen, cedar (35.5%) cypress (22.2%) exceeded 20%. Only significantly higher in compared that non-ACO COPD. Moreover, it contributed an class-dependent manner. Patients cockroach exhibited residual volume, whereas those better diffusion capacity than negative patients. The contribution by receiver operating characteristic curve analysis comparable among total (cutoff value: 158 IU/mL), blood eosinophil count (234/?L), fraction exhaled nitric oxide (31.0 ppb). Conclusions prominent role mite-specific potentially detrimental air trapping were suggested. finding highlights future development treatment targeting as treatable trait